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Mediation analysis using incomplete information from publicly available data sources.
- Source :
-
Statistics in medicine [Stat Med] 2024 Jun 30; Vol. 43 (14), pp. 2695-2712. Date of Electronic Publication: 2024 Apr 12. - Publication Year :
- 2024
-
Abstract
- Our work was motivated by the question whether, and to what extent, well-established risk factors mediate the racial disparity observed for colorectal cancer (CRC) incidence in the United States. Mediation analysis examines the relationships between an exposure, a mediator and an outcome. All available methods require access to a single complete data set with these three variables. However, because population-based studies usually include few non-White participants, these approaches have limited utility in answering our motivating question. Recently, we developed novel methods to integrate several data sets with incomplete information for mediation analysis. These methods have two limitations: (i) they only consider a single mediator and (ii) they require a data set containing individual-level data on the mediator and exposure (and possibly confounders) obtained by independent and identically distributed sampling from the target population. Here, we propose a new method for mediation analysis with several different data sets that accommodates complex survey and registry data, and allows for multiple mediators. The proposed approach yields unbiased causal effects estimates and confidence intervals with nominal coverage in simulations. We apply our method to data from U.S. cancer registries, a U.S.-population-representative survey and summary level odds-ratio estimates, to rigorously evaluate what proportion of the difference in CRC risk between non-Hispanic Whites and Blacks is mediated by three potentially modifiable risk factors (CRC screening history, body mass index, and regular aspirin use).<br /> (© 2024 John Wiley & Sons Ltd.)
- Subjects :
- Humans
United States epidemiology
Risk Factors
Computer Simulation
Aspirin therapeutic use
Incidence
Registries
Health Status Disparities
White People statistics & numerical data
Female
Black or African American statistics & numerical data
Information Sources
Colorectal Neoplasms ethnology
Colorectal Neoplasms epidemiology
Mediation Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0258
- Volume :
- 43
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Statistics in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38606437
- Full Text :
- https://doi.org/10.1002/sim.10076