SOX17: escape route from immune destruction in early CRC.

In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5 ^- (LGR5 ^- ) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.
Competing Interests: Declaration of interests The authors declare no conflicts of interest.
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