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Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury.

Authors :
Lin J
Sun Y
Xia B
Wang Y
Xie C
Wang J
Hu J
Zhu L
Source :
Neuroscience bulletin [Neurosci Bull] 2024 Sep; Vol. 40 (9), pp. 1230-1244. Date of Electronic Publication: 2024 Apr 09.
Publication Year :
2024

Abstract

Disruption of the blood-spinal cord barrier (BSCB) is a critical event in the secondary injury following spinal cord injury (SCI). Mertk has been reported to play an important role in regulating inflammation and cytoskeletal dynamics. However, the specific involvement of Mertk in BSCB remains elusive. Here, we demonstrated a distinct role of Mertk in the repair of BSCB. Mertk expression is decreased in endothelial cells following SCI. Overexpression of Mertk upregulated tight junction proteins (TJs), reducing BSCB permeability and subsequently inhibiting inflammation and apoptosis. Ultimately, this led to enhanced neural regeneration and functional recovery. Further experiments revealed that the RhoA/Rock1/P-MLC pathway plays a key role in the effects of Mertk. These findings highlight the role of Mertk in promoting SCI recovery through its ability to mitigate BSCB permeability and may provide potential targets for SCI repair.<br /> (© 2024. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.)

Details

Language :
English
ISSN :
1995-8218
Volume :
40
Issue :
9
Database :
MEDLINE
Journal :
Neuroscience bulletin
Publication Type :
Academic Journal
Accession number :
38592581
Full Text :
https://doi.org/10.1007/s12264-024-01199-x