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Role of coronary spasm in different anginal syndromes.
- Source :
-
Acta medica Scandinavica. Supplementum [Acta Med Scand Suppl] 1985; Vol. 694, pp. 83-94. - Publication Year :
- 1985
-
Abstract
- Angina pectoris is a clinical syndrome caused by transient myocardial ischaemia due to an imbalance between myocardial oxygen demand and supply. It is now evident that coronary artery spasm plays an important role in the pathogenesis of various forms of angina pectoris. Angina pectoris that is mainly caused by coronary artery spasm (coronary spastic angina) has one or more of the following characteristics: 1) the attack occurs at rest, 2) the attack is associated with ST-segment elevation in the ECG, 3) the attack has a variable exercise threshold, and 4) the attack is suppressed by Ca-antagonists but not by beta-adrenergic blocking agents. On the other hand, angina pectoris that is caused by increased myocardial oxygen demand in the presence of severe and extensive organic stenosis (organic angina) has the following characteristics: 1) the attack is induced by constant amount of exertion irrespective of hour and day and is relieved by rest, 2) the attack is associated with ST-segment depression in the ECG, and 3) the attack is suppressed by beta-adrenergic blocking agents, which decrease myocardial oxygen demand.
- Subjects :
- Angina Pectoris classification
Angina Pectoris, Variant drug therapy
Angiography
Circadian Rhythm
Coronary Vasospasm complications
Coronary Vasospasm diagnostic imaging
Diltiazem therapeutic use
Electrocardiography
Exercise Test
Humans
Nifedipine therapeutic use
Oxygen Consumption
Phentolamine therapeutic use
Propranolol therapeutic use
Angina Pectoris etiology
Angina Pectoris, Variant etiology
Coronary Vasospasm physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0365-463X
- Volume :
- 694
- Database :
- MEDLINE
- Journal :
- Acta medica Scandinavica. Supplementum
- Publication Type :
- Academic Journal
- Accession number :
- 3859197
- Full Text :
- https://doi.org/10.1111/j.0954-6820.1985.tb08804.x