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Heteroions Radii Matching Produced Intensely Luminescent Bismuth-Ag 2 S Nanocrystals for through-Skull NIR-II Imaging of Orthotopic Glioma.
- Source :
-
Nano letters [Nano Lett] 2024 Apr 17; Vol. 24 (15), pp. 4562-4570. Date of Electronic Publication: 2024 Apr 09. - Publication Year :
- 2024
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Abstract
- Heteroions doped Ag <subscript>2</subscript> S nanocrystals (NCs) exhibiting enhanced near-infrared-II emission (NIR-II) hold great promise for glioma diagnosis. Nevertheless, current doped Ag <subscript>2</subscript> S NCs paradoxically improved properties via toxic dopants, and the blood-brain barrier (BBB) constitutes another challenge for orthotopic glioma imaging. Thus, it is urgent to develop biofriendly high-bright Ag <subscript>2</subscript> S NCs with active BBB-penetration for glioma-targeted imaging. Herein, bismuth (Bi) was screened to obtain Bi-Ag <subscript>2</subscript> S NCs with high absolute PLQY (∼13.3%) for its matched ionic-radius (1.03 Å) with Ag <superscript>+</superscript> . The Bi-Ag <subscript>2</subscript> S NCs exhibited a higher luminance and deeper penetration (5-6 mm) than clinical indocyanine green. Upon conjugation with lactoferrin, the NCs acquired BBB-crossing and glioma-targeting abilities. Time-dependent NIR-II-imaging demonstrated their effective accumulation in glioma with skull/scalp intact after intravenous injection. Moreover, the toxic-metal-free NCs exhibited negligible toxicity and great biocompatibility. The success of leveraging the ion-radii comparison may unlock the full potential of doped-Ag <subscript>2</subscript> S NCs in bioimaging and inspire the development of various doped NIR-II NCs.
- Subjects :
- Humans
Bismuth
Radius
Skull
Metal Nanoparticles chemistry
Glioma diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 24
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 38591327
- Full Text :
- https://doi.org/10.1021/acs.nanolett.4c00604