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A photo-responsive self-healing hydrogel loaded with immunoadjuvants and MoS 2 nanosheets for combating post-resection breast cancer recurrence.
- Source :
-
Nanoscale [Nanoscale] 2024 May 02; Vol. 16 (17), pp. 8417-8426. Date of Electronic Publication: 2024 May 02. - Publication Year :
- 2024
-
Abstract
- Tumor recurrence after surgical resection remains a significant challenge in breast cancer treatment. Immune checkpoint blockade therapy, as a promising alternative therapy, faces limitations in combating tumor recurrence due to the low immune response rate. In this study, we developed an implantable photo-responsive self-healing hydrogel loaded with MoS <subscript>2</subscript> nanosheets and the immunoadjuvant R837 (PVA-MoS <subscript>2</subscript> -R837, PMR hydrogel) for in situ generation of tumor-associated antigens at the post-surgical site of the primary tumor, enabling sustained and effective activation of the immune response. This PMR hydrogel exhibited potential for near-infrared (NIR) light response, tissue adhesion, self-healing, and sustained adjuvant release. When implanted at the site after tumor resection, NIR irradiation triggered a photothermal effect, resulting in the ablation of residual cancer cells. The in situ -generated tumor-associated antigens promoted dendritic cell (DC) maturation. In a mouse model, PMR hydrogel-mediated photothermal therapy combined with immune checkpoint blockade effectively inhibited the recurrence of resected tumors, providing new insights for combating post-resection breast cancer recurrence.
- Subjects :
- Animals
Female
Mice
Humans
Cell Line, Tumor
Nanostructures chemistry
Mice, Inbred BALB C
Dendritic Cells drug effects
Dendritic Cells immunology
Dendritic Cells metabolism
Antigens, Neoplasm immunology
Photothermal Therapy
Infrared Rays
Molybdenum chemistry
Molybdenum pharmacology
Disulfides chemistry
Disulfides pharmacology
Breast Neoplasms pathology
Breast Neoplasms therapy
Hydrogels chemistry
Hydrogels pharmacology
Neoplasm Recurrence, Local prevention & control
Adjuvants, Immunologic pharmacology
Adjuvants, Immunologic chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2040-3372
- Volume :
- 16
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Nanoscale
- Publication Type :
- Academic Journal
- Accession number :
- 38591110
- Full Text :
- https://doi.org/10.1039/d4nr00372a