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Efficacy of Brolucizumab in Polyp Regression of Treatment-Naive Polypoidal Choroidal Vasculopathy and Its Effect on 1-Year Treatment Outcome.
- Source :
-
Korean journal of ophthalmology : KJO [Korean J Ophthalmol] 2024 Jun; Vol. 38 (3), pp. 185-193. Date of Electronic Publication: 2024 Apr 08. - Publication Year :
- 2024
-
Abstract
- Purpose: To evaluate the efficacy of intravitreal brolucizumab in polyp regression of treatment-naive polypoidal choroidal vasculopathy (PCV) patients and its effect on 1-year treatment outcome.<br />Methods: Medical records of 31 treatment-naive PCV patients, who received three monthly intravitreal brolucizumab injections followed by as-needed injections for at least a year, were retrospectively reviewed. Visual and anatomical outcomes were evaluated at 3, 6, and 12 months. Complete polyp regression rate and percentage change of vascular lesion and polyp area were evaluated after three monthly injections of brolucizumab. The effect of complete polyp regression and the impact of vascular lesion and polyp reduction rate on 1-year treatment outcome were also evaluated.<br />Results: In terms of visual outcome, best-corrected visual acuity significantly improved after 12-month follow-up (p &lt; 0.001). In terms of anatomical outcome, central macular thickness (CMT) and central choroidal thickness significantly decreased after 12-month follow-up (p &lt; 0.001). Complete polyp regression was observed in 23 patients (74.2%) after three monthly injections. Group with complete polyp regression had a higher rate of achieving dry macula at 3 months (p = 0.026) and fewer number of injections (p &lt; 0.001) compared to the group without complete polyp regression. Higher polyp reduction rate was significantly associated with higher CMT change from baseline at 3 months (p = 0.048) while higher vascular lesion reduction rate was significantly associated with higher CMT change from baseline at 12 months (p = 0.031) and fewer number of injections (p = 0.012).<br />Conclusions: Intravitreal brolucizumab injection effectively improved visual and anatomical outcomes and achieved significant polyp regression in treatment-naive PCV patients. Complete polyp regression and the reduction rate of vascular lesion size and polyp size after loading injection significantly influence the treatment outcome of PCV patients. However, careful monitoring and preoperative warning is warranted due to occurrence of brolucizumab-related IOI.
- Subjects :
- Humans
Male
Female
Retrospective Studies
Aged
Treatment Outcome
Follow-Up Studies
Middle Aged
Fundus Oculi
Choroidal Neovascularization drug therapy
Choroidal Neovascularization diagnosis
Choroidal Neovascularization physiopathology
Time Factors
Choroid Diseases drug therapy
Choroid Diseases diagnosis
Vascular Endothelial Growth Factor A antagonists & inhibitors
Polypoidal Choroidal Vasculopathy
Intravitreal Injections
Visual Acuity
Polyps drug therapy
Polyps diagnosis
Fluorescein Angiography methods
Angiogenesis Inhibitors administration & dosage
Tomography, Optical Coherence methods
Choroid blood supply
Choroid pathology
Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2092-9382
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Korean journal of ophthalmology : KJO
- Publication Type :
- Academic Journal
- Accession number :
- 38584441
- Full Text :
- https://doi.org/10.3341/kjo.2023.0145