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Acer tegmentosum extract-mediated silver nanoparticles loaded chitosan/alginic acid scaffolds enhance healing of E. coli-infected wounds.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 267 (Pt 2), pp. 131389. Date of Electronic Publication: 2024 Apr 04. - Publication Year :
- 2024
-
Abstract
- This work developed Acer tegmentosum extract-mediated silver nanoparticles (AgNPs) loaded chitosan (CS)/alginic acid (AL) scaffolds (CS/AL-AgNPs) to enhance the healing of E. coli-infected wounds. The SEM-EDS and XRD results revealed the successful formation of the CS/AL-AgNPs. FTIR analysis evidenced that the anionic group of AL (-COO-) and cationic amine groups of CS (-NH <subscript>3</subscript> <superscript>+</superscript> ) were ionically crosslinked to form scaffold (CS/AL). The CS/AL-AgNPs exhibited significant antimicrobial activity against both Gram-positive (G+) and Gram-negative (G-) bacterial pathogens, while being non-toxic to red blood cells (RBCs), the hen's egg chorioallantoic membrane (HET-CAM), and a non-cancerous cell line (NIH3T3). Treatment with CS/AL-AgNPs significantly accelerated the healing of E. coli-infected wounds by regulating the collagen deposition and blood parameters as evidenced by in vivo experiments. Overall, these findings suggest that CS/AL-AgNPs are promising for the treatment of infected wounds.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Mice
NIH 3T3 Cells
Escherichia coli Infections drug therapy
Tissue Scaffolds chemistry
Chitosan chemistry
Chitosan pharmacology
Metal Nanoparticles chemistry
Silver chemistry
Silver pharmacology
Wound Healing drug effects
Escherichia coli drug effects
Acer chemistry
Plant Extracts chemistry
Plant Extracts pharmacology
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Alginates chemistry
Alginates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 267
- Issue :
- Pt 2
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 38582461
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.131389