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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation.

Authors :
Chen X
Shen Y
Song Z
Wang X
Yao H
Cai Y
Zhao ZA
Hu B
Source :
Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Sep; Vol. 51 (9), pp. 911-921. Date of Electronic Publication: 2024 Apr 04.
Publication Year :
2024

Abstract

MicroRNAs (miRNAs) play a significant role in axon regeneration following spinal cord injury. However, the functions of numerous miRNAs in axon regeneration within the central nervous system (CNS) remain largely unexplored. Here, we elucidate the positive role of microRNA-2184 (miR-2184) in axon regeneration within zebrafish Mauthner cells (M-cells). The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration, while the specific sponge-induced silencing of miR-2184 leads to impeded regeneration. We show that syt3, a downstream target of miR-2184, negatively regulates axon regeneration, and the regeneration suppression modulated by syt3 depends on its binding to Ca <superscript>2+</superscript> . Furthermore, pharmacological stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon regeneration. Our data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS by modulating the downstream target syt3, providing valuable insights into potential therapeutic strategies.<br />Competing Interests: Conflicts of interest The authors declare that no competing interests exist.<br /> (Copyright © 2024 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1673-8527
Volume :
51
Issue :
9
Database :
MEDLINE
Journal :
Journal of genetics and genomics = Yi chuan xue bao
Publication Type :
Academic Journal
Accession number :
38582297
Full Text :
https://doi.org/10.1016/j.jgg.2024.03.016