Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients.

Objectives: The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC).
Methods: A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited.
Results: The Forced Expiratory Volume in 1 second (FEV _1.0 ), Percent Predicted FEV _1.0 , and FEV _1.0 /Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV _1.0 /FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score.
Conclusions: The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC.
Level of Evidence: Level 4.
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