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Impact of Depressive Symptom Severity on Buprenorphine/Naloxone and Methadone Outcomes in People With Prescription-Type Opioid Use Disorder: Results From a Pragmatic Randomized Controlled Trial.
- Source :
-
Journal of dual diagnosis [J Dual Diagn] 2024 Jul-Sep; Vol. 20 (3), pp. 189-200. Date of Electronic Publication: 2024 Apr 05. - Publication Year :
- 2024
-
Abstract
- Objective: To evaluate the impact of depressive symptom severity on opioid use and treatment retention in individuals with prescription-type opioid use disorder (POUD).<br />Method: We analyzed data from a multi-centric, pragmatic, open-label, randomized controlled trial comparing buprenorphine/naloxone to methadone models of care in 272 individuals with POUD. Opioid use was self-reported every two weeks for 24 weeks using the Timeline Followback. Depressive symptom severity was self-reported with the Beck Depression Inventory at baseline, week 12 and week 24.<br />Results: Baseline depressive symptom severity was not associated with opioid use nor treatment retention. At week 12, moderate depressive symptoms were associated with greater opioid use while mild to severe depressive symptoms were associated with lowered treatment retention. At week 24, moderate depressive symptoms were associated with greater opioid use.<br />Conclusions: Ongoing depressive symptoms lead to poorer outcomes in POUD. Clinicians are encouraged to use integrative approaches to optimize treatment outcomes. This study was registered in ClinicalTrials.gov (NCT03033732) on January 27 <superscript>th</superscript> , 2017, prior to participants enrollment.
- Subjects :
- Humans
Male
Female
Adult
Middle Aged
Treatment Outcome
Narcotic Antagonists therapeutic use
Narcotic Antagonists administration & dosage
Analgesics, Opioid therapeutic use
Analgesics, Opioid administration & dosage
Opioid-Related Disorders complications
Opioid-Related Disorders drug therapy
Depression drug therapy
Depression complications
Methadone therapeutic use
Opiate Substitution Treatment
Buprenorphine, Naloxone Drug Combination therapeutic use
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 1550-4271
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of dual diagnosis
- Publication Type :
- Academic Journal
- Accession number :
- 38580298
- Full Text :
- https://doi.org/10.1080/15504263.2024.2329267