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Metabolites and Cognitive Decline in a Puerto Rican Cohort.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 99 (s2), pp. S345-S353. - Publication Year :
- 2024
-
Abstract
- Background: Recent studies have identified plasma metabolites associated with cognitive decline and Alzheimer's disease; however, little research on this topic has been conducted in Latinos, especially Puerto Ricans.<br />Objective: This study aims to add to the growing body of metabolomics research in Latinos to better understand and improve the health of this population.<br />Methods: We assessed the association between plasma metabolites and global cognition over 12 years of follow-up in 736 participants of the Boston Puerto Rican Health Study (BPRHS). Metabolites were measured with untargeted metabolomic profiling (Metabolon, Inc) at baseline. We used covariable adjusted linear mixed models (LMM) with a metabolite * time interaction term to identify metabolites (of 621 measured) associated with ∼12 years cognitive trajectory.<br />Results: We observed strong inverse associations between medium-chain fatty acids, caproic acid, and the dicarboxylic acids, azelaic and sebacic acid, and global cognition. N-formylphenylalanine, a tyrosine pathway metabolite, was associated with improvement in cognitive trajectory.<br />Conclusions: The metabolites identified in this study are generally consistent with prior literature and highlight a role medium chain fatty acid and tyrosine metabolism in cognitive decline.
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 99
- Issue :
- s2
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 38578885
- Full Text :
- https://doi.org/10.3233/JAD-230053