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Assessment of transabdominal fat volumes as a predictor of prognosis in patients undergoing transcatheter aortic valve replacement.
- Source :
-
The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2024 May; Vol. 40 (5), pp. 1095-1104. Date of Electronic Publication: 2024 Apr 05. - Publication Year :
- 2024
-
Abstract
- Transcatheter aortic valve replacement (TAVR) has emerged as a well-established treatment option for eligible patients with severe aortic stenosis. This study aimed to investigate the correlation between abdominal fat tissue volumes, measured using computed tomography (CT), and all-cause mortality in patients undergoing TAVR. The study included 258 consecutive patients who underwent TAVR at a single center between September 2017 and November 2020. During the preoperative preparation, CT scans were used to perform a semi-quantitative measurement of abdominal fat components. Body mass index (BMI) for each participant was calculated. The relationship between fat parameters and overall survival was determined using multivariable Cox proportional hazards models. Participants had a mean age of 76.8 ± 7.8 years, of whom 32.9% were male. The median follow-up period was 12 months, during which 38 patients (14.7%) died. Both the survivor and non-survivor groups showed comparable risk factors. Regarding transabdominal fat volume parameters, deceased individuals exhibited significantly lower values. However, no significant differences were observed in BMI and transabdominal area measurements. Among transabdominal fat parameters, only subcutaneous fat volume [adjusted Hazard Ratio (aHR) = 0.83, p = 0.045] and total fat volume (TFV) [aHR = 0.82, p = 0.007] were identified as significant predictors of reduced all-cause mortality. Furthermore, TFV demonstrated the highest discriminative performance with a threshold of ≤ 9.1 L (AUC = 0.751, p < 0.001, sensitivity 71.1%, specificity 70.9%). Preoperative CT-based abdominal fat volume parameters, particularly TFV, can serve as potential predictors of survival in patients undergoing TAVR.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Subjects :
- Humans
Male
Female
Aged
Risk Factors
Aged, 80 and over
Risk Assessment
Treatment Outcome
Time Factors
Retrospective Studies
Tomography, X-Ray Computed
Aortic Valve diagnostic imaging
Aortic Valve surgery
Aortic Valve physiopathology
Abdominal Fat diagnostic imaging
Severity of Illness Index
Transcatheter Aortic Valve Replacement mortality
Transcatheter Aortic Valve Replacement adverse effects
Aortic Valve Stenosis diagnostic imaging
Aortic Valve Stenosis surgery
Aortic Valve Stenosis mortality
Aortic Valve Stenosis physiopathology
Predictive Value of Tests
Adiposity
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8312
- Volume :
- 40
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The international journal of cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 38578361
- Full Text :
- https://doi.org/10.1007/s10554-024-03079-x