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Mechanisms and potential applications of COPS6 in pan-cancer therapy.

Authors :
Wu T
Ji MR
Luo LX
Source :
World journal of clinical oncology [World J Clin Oncol] 2024 Mar 24; Vol. 15 (3), pp. 367-370.
Publication Year :
2024

Abstract

The COP9 signalosome subunit 6 (COPS6) is abnormally overexpressed in many malignancies, yet its precise role in carcinogenesis is unknown. To gain a better understanding of COPS6's role, the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns, prognostic value, gene mutations, immune infiltration, correlation analysis, and functional enrichment assessment. Results showed that COPS6 was highly correlated with prognosis, immune cell infiltration level, tumor mutation burden, and microsatellite instability in patients with a range of tumor types. This suggests that COPS6 may be a potential target for cancer treatment. Overall, this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.<br />Competing Interests: Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)

Details

Language :
English
ISSN :
2218-4333
Volume :
15
Issue :
3
Database :
MEDLINE
Journal :
World journal of clinical oncology
Publication Type :
Editorial & Opinion
Accession number :
38576589
Full Text :
https://doi.org/10.5306/wjco.v15.i3.367