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Risk of Developing Hypertension in Atopic Dermatitis Patients Receiving Long-term and Low-dose Cyclosporine: A Nationwide Population-based Cohort Study.
- Source :
-
Annals of dermatology [Ann Dermatol] 2024 Apr; Vol. 36 (2), pp. 112-119. - Publication Year :
- 2024
-
Abstract
- Background: Cyclosporine (CS) is a first-line immunosuppressive agent used to manage moderate to severe atopic dermatitis (AD). To date, the risk of developing hypertension associated with the long-term use of low-dose CS in AD patients is understudied.<br />Objective: To determine the cumulative dose-dependent effect of CS on the risk of developing hypertension in patients with AD.<br />Methods: A nationwide population-based retrospective cohort with 1,844,009 AD patients was built from the Korean National Health Insurance System database from 2005 to 2009. A Cox proportional-hazard regression analysis was performed according to patients' CS treatment history adjusted for potential confounders.<br />Results: Current use of CS was associated with an increased risk of developing hypertension (adjusted hazard ratio, 4.442; 95% confidence interval, 3.761-5.247). Among the current CS users, a higher cumulative dose of CS (≥39,725 mg) or longer cumulative use of CS (≥182 days), was significantly associated with an increased risk of developing hypertension.<br />Conclusion: The incidence of CS-associated hypertension is very low when using low-dose treatment regimens for AD. However, the current use or a high cumulative dose of CS for treating patients with AD increases the risk of developing hypertension. Precaution is needed when prescribing CS for long-term treatment of AD.<br />Competing Interests: The authors have nothing to disclose.<br /> (© 2024 The Korean Dermatological Association and The Korean Society for Investigative Dermatology.)
Details
- Language :
- English
- ISSN :
- 2005-3894
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 38576249
- Full Text :
- https://doi.org/10.5021/ad.23.099