Back to Search
Start Over
Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion.
- Source :
-
Science (New York, N.Y.) [Science] 2024 Apr 05; Vol. 384 (6691), pp. 66-73. Date of Electronic Publication: 2024 Apr 04. - Publication Year :
- 2024
-
Abstract
- Asthma is deemed an inflammatory disease, yet the defining diagnostic feature is mechanical bronchoconstriction. We previously discovered a conserved process called cell extrusion that drives homeostatic epithelial cell death when cells become too crowded. In this work, we show that the pathological crowding of a bronchoconstrictive attack causes so much epithelial cell extrusion that it damages the airways, resulting in inflammation and mucus secretion in both mice and humans. Although relaxing the airways with the rescue treatment albuterol did not affect these responses, inhibiting live cell extrusion signaling during bronchoconstriction prevented all these features. Our findings show that bronchoconstriction causes epithelial damage and inflammation by excess crowding-induced cell extrusion and suggest that blocking epithelial extrusion, instead of the ensuing downstream inflammation, could prevent the feed-forward asthma inflammatory cycle.
- Subjects :
- Animals
Humans
Mice
Inflammation pathology
Signal Transduction
Ion Channels antagonists & inhibitors
Lysophospholipids antagonists & inhibitors
Sphingosine analogs & derivatives
Sphingosine antagonists & inhibitors
Asthma pathology
Asthma physiopathology
Bronchoconstriction drug effects
Bronchi pathology
Bronchi physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 384
- Issue :
- 6691
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 38574138
- Full Text :
- https://doi.org/10.1126/science.adk2758