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Redefining hyperviscosity in acute leukemia: Potential implications for red cell transfusions in the microvasculature.

Authors :
Musick JO
Williams EK
Fibben KS
Zhang DY
Caruso C
Sakurai Y
Tran R
Kemp ML
Lam WA
Source :
American journal of hematology [Am J Hematol] 2024 Jun; Vol. 99 (6), pp. 1103-1107. Date of Electronic Publication: 2024 Apr 04.
Publication Year :
2024

Abstract

Hyperleukocytosis is an emergency of acute leukemia leading to blood hyperviscosity, potentially resulting in life-threatening microvascular obstruction, or leukostasis. Due to the high number of red cells in the circulation, hematocrit/hemoglobin levels (Hct/Hgb) are major drivers of blood viscosity, but how Hct/Hgb mediates hyperviscosity in acute leukemia remains unknown. In vivo hemorheological studies are difficult to conduct and interpret due to issues related to visualizing and manipulating the microvasculature. To that end, a multi-vessel microfluidic device recapitulating the size-scale and geometry of the microvasculature was designed to investigate how Hct/Hgb interacts with acute leukemia to induce "in vitro" leukostasis. Using patient samples and cell lines, the degree of leukostasis was different among leukemia immunophenotypes with respect to white blood cell (WBC) count and Hct/Hgb. Among lymphoid immunophenotypes, severe anemia is protective against in vitro leukostasis and Hct/Hgb thresholds became apparent above which in vitro leukostasis significantly increased, to a greater extent with B-cell acute lymphoblastic leukemia (ALL) versus T-cell ALL. In vitro leukostasis in acute myeloid leukemia was primarily driven by WBC with little interaction with Hct/Hgb. This sets the stage for prospective clinical studies assessing how red cell transfusion may affect leukostasis risk in immunophenotypically different acute leukemia patients.<br /> (© 2024 Wiley Periodicals LLC.)

Details

Language :
English
ISSN :
1096-8652
Volume :
99
Issue :
6
Database :
MEDLINE
Journal :
American journal of hematology
Publication Type :
Academic Journal
Accession number :
38572662
Full Text :
https://doi.org/10.1002/ajh.27308