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Coagulation activity and thrombotic risk following high-volume endurance exercise in recreationally active cyclists.
- Source :
-
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2024 May 01; Vol. 136 (5), pp. 1284-1290. Date of Electronic Publication: 2024 Apr 04. - Publication Year :
- 2024
-
Abstract
- Despite the prognostic effect of physical activity, acute bouts of high-volume endurance exercise can induce cardiac stress and postexercise hypercoagulation associated with increased thrombotic risk. The aim of this study was to explore the effect of high-volume endurance exercise on coagulation and thrombotic activity in recreational cyclists. Thirty-four recreational cyclists completed 4.8 ± 0.3 h of cycling at 45 ± 5% of maximal power output on a bicycle ergometer. Intravenous blood samples were collected preexercise, immediately postexercise, 24 and 48 h postexercise, and analyzed for brain natriuretic peptide (BNP), cardiac troponin (cTn), C-reactive protein (CRP), D-dimer, thrombin-antithrombin (TAT) complex, tissue factor (TF), tissue factor pathway inhibitor (TFPI), and TF-to-TFPI ratio (TF:TFPI). An increase in cTn was observed postexercise ( P < 0.001). CRP concentrations were increased at 24 and 48 h postexercise compared with preexercise concentrations ( P ≤ 0.001). TF was elevated at 24 h postexercise ( P < 0.031) and TFPI was higher immediately postexercise ( P < 0.044) compared with all other time points. TF:TFPI was increased at 24 and 48 h postexercise compared with preexercise ( P < 0.025). TAT complex was reduced at 48 h postexercise compared with preexercise ( P = 0.015), D-dimer was higher immediately postexercise compared with all other time points ( P ≤ 0.013). No significant differences were observed in BNP ( P > 0.05). High-volume endurance cycling induced markers of cardiac stress among recreational cyclists. However, plasma coagulation and fibrinolytic activity suggest no increase in thrombotic risk after high-volume endurance exercise. NEW & NOTEWORTHY In this study, a high-volume endurance exercise protocol induced markers of cardiac stress and altered plasma coagulation and fibrinolytic activity for up to 48 h in recreationally active cyclists. However, analysis of coagulation biomarkers indicates no increase in thrombotic risk when appropriate hydration and rest protocols are implemented.
- Subjects :
- Humans
Male
Adult
C-Reactive Protein metabolism
Fibrin Fibrinogen Degradation Products metabolism
Exercise physiology
Natriuretic Peptide, Brain blood
Young Adult
Lipoproteins blood
Biomarkers blood
Antithrombin III metabolism
Risk Factors
Peptide Hydrolases blood
Bicycling physiology
Blood Coagulation physiology
Thrombosis physiopathology
Thrombosis blood
Thrombosis etiology
Physical Endurance physiology
Thromboplastin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1601
- Volume :
- 136
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of applied physiology (Bethesda, Md. : 1985)
- Publication Type :
- Academic Journal
- Accession number :
- 38572538
- Full Text :
- https://doi.org/10.1152/japplphysiol.00824.2023