Back to Search
Start Over
Disease-free survival and the prognostic factors affecting disease-free survival in patients with medullary thyroid carcinoma: a multicenter cohort study.
- Source :
-
Endocrine [Endocrine] 2024 Sep; Vol. 85 (3), pp. 1300-1309. Date of Electronic Publication: 2024 Apr 03. - Publication Year :
- 2024
-
Abstract
- Purpose: Despite several factors that may have been associated with poor disease-free survival (DFS) in patients with medullary thyroid carcinoma (MTC), only a few studies have evaluated the prognostic factors affecting DFS in MTC patients. Therefore, this study evaluated the prognostic factors affecting DFS, in a large number of patients with MTC.<br />Methods: Patients treated for MTC were retrospectively analyzed. Patients were stratified as having persistent/recurrent disease and no evidence of disease (NOD) at the last follow-up. The factors affecting DFS after the initial therapy and during the follow-up period were investigated.<br />Results: This study comprised 257 patients [females 160 (62.3%), hereditary disease 48 (18.7%), with a mean follow-up time of 66.8 ± 48.5 months]. Persistent/recurrent disease and NOD were observed in 131 (51%) and 126 (49%) patients, respectively. In multivariate analysis, age > 55 (HR: 1.65, p = 0.033), distant metastasis (HR: 2.41, p = 0.035), CTN doubling time (HR: 2.7, p = 0.031), and stage III vs. stage II disease (HR 3.02, p = 0.048) were independent predictors of persistent/recurrent disease. Although 9 (8%) patients with an excellent response after the initial therapy experienced a structural recurrence, the absence of an excellent response was the strongest predictor of persistent/recurrent disease (HR: 5.74, p < 0.001).<br />Conclusions: The absence of an excellent response after initial therapy is the strongest predictor of a worse DFS. However, a significant proportion of patients who achieve an excellent response could experience a structural recurrence. Therefore, careful follow-up of patients, including those achieving an excellent response is essential.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Prognosis
Retrospective Studies
Disease-Free Survival
Aged
Neoplasm Recurrence, Local
Cohort Studies
Young Adult
Adolescent
Thyroidectomy
Thyroid Neoplasms mortality
Thyroid Neoplasms pathology
Thyroid Neoplasms therapy
Carcinoma, Neuroendocrine mortality
Carcinoma, Neuroendocrine pathology
Carcinoma, Neuroendocrine therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0100
- Volume :
- 85
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endocrine
- Publication Type :
- Academic Journal
- Accession number :
- 38570387
- Full Text :
- https://doi.org/10.1007/s12020-024-03809-0