Back to Search
Start Over
Microglia in retinal angiogenesis and diabetic retinopathy.
- Source :
-
Angiogenesis [Angiogenesis] 2024 Aug; Vol. 27 (3), pp. 311-331. Date of Electronic Publication: 2024 Apr 02. - Publication Year :
- 2024
-
Abstract
- Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the growth of new blood vessels in the retina at an advanced, proliferative stage. Microglia are a resident immune population in the central nervous system, known to play a crucial role in regulating retinal angiogenesis in both physiological and pathological conditions, including diabetic retinopathy. Physiologically, they are located close to blood vessels and are essential for forming new blood vessels (neovascularization). In diabetic retinopathy, microglia become widely activated, showing a distinct polarization phenotype that leads to their accumulation around neovascular tufts. These activated microglia induce pathogenic angiogenesis through the secretion of various angiogenic factors and by regulating the status of endothelial cells. Interestingly, some subtypes of microglia simultaneously promote the regression of neovascularization tufts and normal angiogenesis in neovascularization lesions. Modulating the state of microglial activation to ameliorate neovascularization thus appears as a promising potential therapeutic approach for managing diabetic retinopathy.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Humans
Angiogenesis metabolism
Angiogenesis pathology
Retina pathology
Retina metabolism
Retinal Vessels pathology
Retinal Vessels metabolism
Diabetic Retinopathy pathology
Diabetic Retinopathy metabolism
Microglia pathology
Microglia metabolism
Retinal Neovascularization pathology
Retinal Neovascularization metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7209
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Angiogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 38564108
- Full Text :
- https://doi.org/10.1007/s10456-024-09911-1