Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF.

The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.
Competing Interests: Samples were collected with support of a National Health & Medical Research Council (NHMRC) of Australia Project Grant (GNT1159721) to Drs Marques and Kaye. Dr Kaye is the recipient of an NHMRC Investigator Grant (Level 3). Dr O’Sullivan is supported by an National Heart Foundation (NHF) Future Leader Fellowship (Level 2) and an New South Wales early to mid career (NSW EMCR) award. Dr Marques is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation, a National Heart Foundation Future Leader Fellowship (105663), and NHMRC Emerging Leader Grant (GNT2017382). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(© 2024 The Authors.)