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Digitally Controlled Printing of Bioink Barriers for Paper-Based Analytical Devices: An Environmentally Friendly One-Step Approach.
- Source :
-
Analytical chemistry [Anal Chem] 2024 Apr 09; Vol. 96 (14), pp. 5349-5356. Date of Electronic Publication: 2024 Mar 30. - Publication Year :
- 2024
-
Abstract
- The patterning of hydrophilic paper with hydrophobic materials has emerged as an interesting method for the fabrication of paper-based devices (PADs). Herein, we demonstrate a digitally automated, easy, low-cost, eco-friendly, and readily available method to create highly hydrophobic barriers on paper that can be promptly employed with PADs by simply using a bioink made with rosin, a commercially available natural resin obtained from conifer trees. The bioink can be easily delivered with the use of a ballpoint pen to produce water- and organic solvent-resistant barriers, showing superior properties when compared to other methods such as wax-printing or permanent markers. The approach enables the pen to be attached to a commercially available cutting printer to perform the semiautomated fabrication of hydrophobic barriers for PADs. With the aid of digitally controlled optimization, together with features of machine learning and design of experiments, we show a thorough investigation on the barrier strength that can be further adjusted to the desired application's needs. Then, we explored the barrier sturdiness across various uses, such as wide range aqueous pH sensing and the harsh acidic/organic conditions needed for the colorimetric detection of cholecalciferol.
- Subjects :
- Solvents
Printing methods
Printing, Three-Dimensional
Paper
Water
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6882
- Volume :
- 96
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Analytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38554084
- Full Text :
- https://doi.org/10.1021/acs.analchem.3c03801