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Supramolecular Hydrogels and Water Channels of Differing Diameters from Dipeptide Isomers.
- Source :
-
Biomacromolecules [Biomacromolecules] 2024 Apr 08; Vol. 25 (4), pp. 2476-2485. Date of Electronic Publication: 2024 Mar 29. - Publication Year :
- 2024
-
Abstract
- Dipeptides stereoisomers and regioisomers composed of norleucine (Nle) and phenylalanine (Phe) self-assemble into hydrogels under physiological conditions that are suitable for cell culture. The supramolecular behavior, however, differs as the packing modes comprise amphipathic layers or water channels, whose diameter is defined by either four or six dipeptide molecules. A variety of spectroscopy, microscopy, and synchrotron-radiation-based techniques unveil fine details of intermolecular interactions that pinpoint the relationship between the chemical structure and ability to form supramolecular architectures that define soft biomaterials.
- Subjects :
- Water chemistry
Stereoisomerism
Microscopy
Dipeptides chemistry
Hydrogels chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4602
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 38551400
- Full Text :
- https://doi.org/10.1021/acs.biomac.3c01439