Back to Search
Start Over
Multi- and extensively drug resistant Escherichia coli isolated from South African children under 5 years old with diarrhoea.
- Source :
-
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Jun; Vol. 109 (2), pp. 116279. Date of Electronic Publication: 2024 Mar 24. - Publication Year :
- 2024
-
Abstract
- Background: Globally, millions of children die as a result of diarrhoea and/or antimicrobial resistant infections. Diarrhoeagenic Escherichia coli (DEC) are responsible for a substantial proportion of cases of diarrhoea in South Africa and sub-Saharan Africa. Effective treatments (including the use of antimicrobials) are therefore essential.<br />Methodology: E. coli isolated from children under the age of five were subjected to antimicrobial susceptibility testing using the Vitek 2® compact automated system (bioMérieux Inc., France) and categorized as multidrug or extensively drug resistant (MDR or XDR).<br />Results: Almost all isolates (164/166, 98.8 %) were categorized as MDR with 4.9 % (9/166) categorized as XDR. The majority of isolates (153/166, 92.2 %) were also phenotypically classified as extended-spectrum β-lactamase (ESBL) producers. More than half of these isolates (78/153, 51.0 %) were subjected to PCR for genes associated with ESBL production. More than half (45/78, 57.7 %) of the isolates tested were PCR positive for at least one ESBL gene or gene group and 11.5 % (9/78) were positive for two ESBL genes or gene groups.<br />Discussion: There is a need to strengthen antimicrobial resistance surveillance in South Africa and improve infection prevention and control measures. There is also a need to review the current South African Treatment Guidelines as outlined by the South African Essential Drugs Programme.<br />Competing Interests: Declaration of competing interest The authors have no conflicting financial or non-financial interests.<br /> (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
South Africa epidemiology
Infant
Child, Preschool
Male
Female
Infant, Newborn
Diarrhea microbiology
Escherichia coli Infections microbiology
Escherichia coli Infections epidemiology
Escherichia coli drug effects
Escherichia coli genetics
Escherichia coli isolation & purification
Drug Resistance, Multiple, Bacterial genetics
Microbial Sensitivity Tests
Anti-Bacterial Agents pharmacology
beta-Lactamases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0070
- Volume :
- 109
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diagnostic microbiology and infectious disease
- Publication Type :
- Academic Journal
- Accession number :
- 38547800
- Full Text :
- https://doi.org/10.1016/j.diagmicrobio.2024.116279