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Risk factors for treatment failure in multidrug resistant tuberculosis in Tunisia: An analytic study.
- Source :
-
La Tunisie medicale [Tunis Med] 2024 Jan 05; Vol. 102 (1), pp. 44-48. Date of Electronic Publication: 2024 Jan 05. - Publication Year :
- 2024
-
Abstract
- Introduction-Aim: The emergence of multidrug resistant tuberculosis (MDR-TB) is a threat to global public health. The aim of our study was to determine risk factors for treatment failure in MDR-TB.<br />Methods: Retrospective study conducted between January 2000 and March 2019 including patients with MDR-TB. Characteristics of patients with therapeutic failure were compared to cured ones. Logistic regression analysis was used to identify risk factors for treatment failure.<br />Results: Our study included 140 patients aged of 42±13 years (18-80). Fifty-seven percent of patients had treatment success and 12% had treatment failure. In multivariate logistic regression analysis, treatment failure was associated with age over 45 years (OR=1.05; 95%CI, 1.024-7.736;p=0.014), primary education level and illiteracy (OR=5.022; 95%CI, 1.316-19.161;p=0,018), history of incarceration (OR=3.291; 95%CI, 1.291-21.083;p=0.016), undernutrition (OR=4.544; 95%CI, 2.304-54.231;p=0,027), extensive TB (OR=6.406; 95%CI, 1.761-23.922; p=0.038), initial high grade positive smears (OR=1.210; 95%CI, 1.187-32.657; p=0.045), positive smear culture at 90 days of treatment (OR=6.871, 95%CI, 3.824-23.541; p=0.003), poor adherence (OR=6.110; 95%CI, 2.740-12.450; p=0.021) and occurrence of psychiatric adverse events (OR=3.644 95%CI, 2.560- 27.268; p=0.041).<br />Conclusion: Therapeutic education, nutritional and psychological support and close follow-up are strongly recommended to optimize the prognosis of MDR-TB.
Details
- Language :
- English
- ISSN :
- 2724-7031
- Volume :
- 102
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- La Tunisie medicale
- Publication Type :
- Academic Journal
- Accession number :
- 38545729
- Full Text :
- https://doi.org/10.62438/tunismed.v102i1.4521