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Risk of Esophageal Adenocarcinoma After Bariatric Surgery: A Meta-Analysis of Retrospective Studies.
- Source :
-
Obesity surgery [Obes Surg] 2024 May; Vol. 34 (5), pp. 1726-1736. Date of Electronic Publication: 2024 Mar 27. - Publication Year :
- 2024
-
Abstract
- Purpose: This study aims to systematically review and meta-analyze the evidence on the risk of esophageal adenocarcinoma (EAC) following metabolic and bariatric surgery (MBS).<br />Materials and Methods: A systematic literature search was conducted on the China National Knowledge Infrastructure (CNKI), Wanfang, EMBASE, MEDLINE, Web of Science, The Cochrane Library, and PubMed databases. Meta-analysis utilized odds ratios (ORs) and 95% confidence intervals (CIs) to analyze the correlation between MBS and the risk of EAC. Meta-analysis was performed using STATA software (version 12.0).<br />Results: Fourteen studies involving patients with obesity undergoing bariatric surgery and control groups receiving conventional treatment were included. The meta-analysis indicated a reduction in the overall incidence of esophageal cancer after bariatric surgery (OR = 0.69, 95% CI: 0.51-0.95, P = 0.022). Subgroup analysis results demonstrated a decreased risk of EAC in European patients with obesity undergoing MBS treatment (OR: 0.60, 95% CI: 0.38-0.95, P = 0.028). In studies with a sample size greater than or equal to 100,000 patients, the risk of EAC in patients with obesity undergoing MBS was significantly lower than the non-surgery group (OR: 0.59, 95% CI: 0.42-0.83, P = 0.003). Articles published before 2020 and those published in 2020 or earlier showed a significant difference in the incidence of EAC between the surgery and non-surgery groups (OR: 0.57, 95% CI: 0.43-0.75, P < 0.001). The risk of EAC in patients with obesity with a follow-up time of less than 5 years was statistically significant (OR: 0.46, 95% CI: 0.25-0.82, P = 0.009).<br />Conclusion: Our meta-analysis results suggest a reduced risk of esophageal cancer in patients with obesity after bariatric surgery.<br />Prospero Registration: CRD 42024505177.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Retrospective Studies
Obesity, Morbid surgery
Obesity, Morbid complications
Incidence
Female
Risk Factors
Male
Middle Aged
Adult
China epidemiology
Obesity complications
Esophageal Neoplasms epidemiology
Esophageal Neoplasms surgery
Bariatric Surgery
Adenocarcinoma epidemiology
Adenocarcinoma surgery
Adenocarcinoma etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1708-0428
- Volume :
- 34
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Obesity surgery
- Publication Type :
- Academic Journal
- Accession number :
- 38536625
- Full Text :
- https://doi.org/10.1007/s11695-024-07190-9