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[Health status and quality of life in β-thalassemia adults in Marseille, France].
- Source :
-
La Revue de medecine interne [Rev Med Interne] 2024 Apr; Vol. 45 (4), pp. 187-193. Date of Electronic Publication: 2024 Mar 21. - Publication Year :
- 2024
-
Abstract
- Introduction: The life expectancy of β-thalassemia patients has increased over the last 20 years. In this study, we evaluated the current health status and quality of life of these patients managed in a reference center in Marseille.<br />Methods: This is a single-center, descriptive study conducted between June and August 2019 in patients over 18 years of age with β-thalassemia major or intermedia. Clinical and paraclinical data were collected retrospectively and the SF-36 health survey questionnaire was proposed to each patient.<br />Results: 43 of 64 selected patients were included and divided into 2 groups: 35 patients with transfusion-dependent β-thalassemia and 8 patients with non-transfusion-dependent β-thalassemia. Liver iron overload is the most frequent complication, present in 80% of transfusion-dependent and 62.5% of non-transfusion-dependent patients. Cardiac iron overload is present only in the transfusion dependent β-thalassemia group (20%). Hypogonadotropic hypogonadism remains the most common endocrine disorder (41.9%) followed by osteoporosis (37.2%). Among the 31 patients who completed the SF-36 questionnaire, physical and mental quality of life scores were lowered in transfusion dependent (respectively 42.7 and 46.8) as in non-transfusion-dependent patients (respectively 43.8 and 28.9).<br />Conclusion: Despite an improvement in medical care, our patients with β-thalassemia show an alteration in their quality of life that will need to be characterized in the entire French cohort.<br /> (Copyright © 2024 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Humans
France epidemiology
Male
Female
Adult
Retrospective Studies
Young Adult
Middle Aged
Blood Transfusion statistics & numerical data
Iron Overload epidemiology
Iron Overload etiology
Surveys and Questionnaires
Adolescent
Quality of Life
beta-Thalassemia therapy
beta-Thalassemia epidemiology
beta-Thalassemia complications
beta-Thalassemia psychology
Health Status
Subjects
Details
- Language :
- French
- ISSN :
- 1768-3122
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- La Revue de medecine interne
- Publication Type :
- Academic Journal
- Accession number :
- 38519305
- Full Text :
- https://doi.org/10.1016/j.revmed.2024.01.005