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Non-sclerosing (T-cell) and sclerosing (B-cell) lymphocytic lobulitis in diagnostic breast biopsies: Clinical, imaging, and pathologic features.
- Source :
-
Human pathology [Hum Pathol] 2024 Apr; Vol. 146, pp. 28-34. Date of Electronic Publication: 2024 Mar 20. - Publication Year :
- 2024
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Abstract
- Lymphocytic lobulitis (LL) is characterized by prominent lymphocytic infiltrates centered on lobules. Sclerosing lymphocytic lobulitis (SCLL) associated with diabetes mellitus (DM) or autoimmune disease (AI) was the first type to be described. Subsequently, non-sclerosing LL (NSCLL) was reported as an incidental finding in prophylactic mastectomies due to high risk germline mutations or a family history of breast cancer. The two types of LL were distinguished by stromal features and a predominant population of B-cells in the former and T-cells in the latter. In this study, 8 cases of NSCLL detected clinically or by screening were compared to 44 cases of SCLL. One case of NSCLL presented as a palpable mass, 2 as masses on screening, and 5 as MRI enhancement. In contrast, 80% of SCLL cases presented as palpable masses. Half the cases of NSCLL were associated with a BRCA1 or 2 mutation compared to 1 case of SCLL (2%). Three additional cases of NSCLL were associated with a strong family and/or personal history of breast cancer. Almost half (52%) of SCLL cases were associated with DM or AI, but only 25% of NSCLL. Immunoperoxidase studies confirmed a predominance of T-cells in NSCLL and B-cells in SCLL associated with DM or AI. It is important for pathologists to be aware of this new observation that NSCLL can be detected as a palpable mass or an imaging finding in diagnostic biopsies, as its presence can be indicative of a significant risk for breast cancer.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. Acknowledgement Assistance with preparation of the figures was provided by Mary E. Lester (marylesterdesign.com).<br /> (Copyright © 2024. Published by Elsevier Inc.)
- Subjects :
- Humans
Female
Middle Aged
Adult
Biopsy
Aged
Sclerosis
Breast pathology
Breast diagnostic imaging
Magnetic Resonance Imaging
Genetic Predisposition to Disease
Mutation
Autoimmune Diseases pathology
Breast Diseases pathology
Breast Diseases diagnosis
BRCA1 Protein genetics
BRCA2 Protein genetics
Mammography
Predictive Value of Tests
B-Lymphocytes pathology
T-Lymphocytes pathology
T-Lymphocytes immunology
Breast Neoplasms pathology
Breast Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 38518977
- Full Text :
- https://doi.org/10.1016/j.humpath.2024.03.006