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Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6.
- Source :
-
Aging [Aging (Albany NY)] 2024 Mar 20; Vol. 16 (6), pp. 5050-5064. Date of Electronic Publication: 2024 Mar 20. - Publication Year :
- 2024
-
Abstract
- Purpose: This study explores the potential of Omilancor in treating Intervertebral Disc Degeneration (IDD) through MAP2K6 targeting.<br />Methods: We analyzed mRNA microarray datasets to pinpoint MAP2K6 as a key regulator implicated in IDD progression. Follow-up studies demonstrated that cisplatin (DDP) could prompt cellular senescence in vitro by upregulating MAP2K6 expression. Through molecular docking and other analyses, we identified Omilancor as a compound capable of binding to MAP2K6. This interaction effectively impeded the cellular senescence induced by DDP.<br />Results: We further showed that administration of Omilancor could significantly alleviate the degeneration of IVDs in annulus fibrosus puncture-induced rat model.<br />Conclusions: Omilancor shows promise as a treatment for IDD by targeting MAP2K6-mediated cellular senescence.
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 38517363
- Full Text :
- https://doi.org/10.18632/aging.205588