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Protective effect of liver X receptor on cigarette smoke and lipopolysaccharide induced airway inflammation and emphysema in mice.
- Source :
-
Experimental lung research [Exp Lung Res] 2024; Vol. 50 (1), pp. 53-64. Date of Electronic Publication: 2024 Mar 21. - Publication Year :
- 2024
-
Abstract
- Objective: The aim of this study is to assess the impact of Liver X receptors (LXRs) on airway inflammation, airway remodeling, and lipid deposition induced by cigarette smoke and lipopolysaccharide (LPS) exposure in the lung.<br />Methods: Wild mice and LXR-deficient mice were exposed to cigarette smoke and LPS to induce airway inflammation and remodeling. In addition, some wild mice received intraperitoneal treatment with the LXR agonist GW3965 before exposure to cigarette smoke and LPS. Lung tissue and bronchoalveolar lavage fluid were collected to evaluate airway inflammation, airway remodeling and lipid deposition.<br />Results: Exposure to cigarette smoke and LPS resulted in airway inflammation, emphysema and lipid accumulation in wild mice. These mice also exhibited downregulated LXRα and ABCA1 in the lung. Treatment with GW3965 mitigated inflammation, remodeling and lipid deposition, while the deletion of LXRs exacerbated these effects. Furthermore, GW3965 treatment following exposure to cigarette smoke and LPS increased LXRα and ABCA1 expression and attenuated MyD88 expression in wild mice.<br />Conclusion: LXRs demonstrate the potential to mitigate cigarette smoke and LPS- induced airway inflammation, emphysema and lipid disposition in mice.
- Subjects :
- Animals
Mice
Airway Remodeling
Bronchoalveolar Lavage Fluid
Inflammation drug therapy
Inflammation metabolism
Lipopolysaccharides pharmacology
Liver X Receptors metabolism
Lung metabolism
Mice, Inbred C57BL
Benzoates
Benzylamines
Cigarette Smoking adverse effects
Emphysema metabolism
Pulmonary Emphysema
Subjects
Details
- Language :
- English
- ISSN :
- 1521-0499
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental lung research
- Publication Type :
- Academic Journal
- Accession number :
- 38509754
- Full Text :
- https://doi.org/10.1080/01902148.2024.2329436