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Genetic risk factors for drug-induced long QT syndrome: findings from a large real-world case-control study.

Authors :
Lopez-Medina AI
Campos-Staffico AM
A Chahal CA
Volkers I
Jacoby JP
Berenfeld O
Luzum JA
Source :
Pharmacogenomics [Pharmacogenomics] 2024 Feb; Vol. 25 (3), pp. 117-131. Date of Electronic Publication: 2024 Mar 20.
Publication Year :
2024

Abstract

Aim: Drug-induced long QT syndrome (diLQTS), an adverse effect of many drugs, can lead to sudden cardiac death. Candidate genetic variants in cardiac ion channels have been associated with diLQTS, but several limitations of previous studies hamper clinical utility. Materials & methods: Thus, the purpose of this study was to assess the associations of KCNE1 -D85N, KCNE2 -I57T and SCN5A -G615E with diLQTS in a large observational case-control study (6,083 self-reported white patients treated with 27 different high-risk QT-prolonging medications; 12.0% with diLQTS). Results: KCNE1 -D85N significantly associated with diLQTS (adjusted odds ratio: 2.24 [95% CI: 1.35-3.58]; p = 0.001). Given low minor allele frequencies, the study had insufficient power to analyze KCNE2 -I57T and SCN5A -G615E. Conclusion: KCNE1 -D85N is a risk factor for diLQTS that should be considered in future clinical practice guidelines.

Details

Language :
English
ISSN :
1744-8042
Volume :
25
Issue :
3
Database :
MEDLINE
Journal :
Pharmacogenomics
Publication Type :
Academic Journal
Accession number :
38506312
Full Text :
https://doi.org/10.2217/pgs-2023-0229