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Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication.
- Source :
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Angewandte Chemie (Weinheim an der Bergstrasse, Germany) [Angew Chem Weinheim Bergstr Ger] 2021 Aug 09; Vol. 133 (33), pp. 18292-18299. Date of Electronic Publication: 2021 Jul 09. - Publication Year :
- 2021
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Abstract
- The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti-virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D models of the structure and dynamics of key regions of the 5' UTR of the SARS-CoV-2 genome. Furthermore, we determine the binding of metallo-supramolecular helicates (cylinders) to this RNA structure. These nano-size agents are uniquely able to thread through RNA junctions and we identify their binding to a 3-base bulge and the central cross 4-way junction located in stem loop 5. Finally, we show these RNA-binding cylinders suppress SARS-CoV-2 replication, highlighting their potential as novel anti-viral agents.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2021 The Authors. Angewandte Chemie published by Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 0044-8249
- Volume :
- 133
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 38505190
- Full Text :
- https://doi.org/10.1002/ange.202104179