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No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts.
- Source :
-
Diabetologia [Diabetologia] 2024 Jun; Vol. 67 (6), pp. 1023-1028. Date of Electronic Publication: 2024 Mar 19. - Publication Year :
- 2024
-
Abstract
- Aims/hypothesis: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.<br />Methods: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.<br />Results: There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.<br />Conclusions/interpretation: Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Pregnancy
Female
Docosahexaenoic Acids administration & dosage
Adult
Denmark epidemiology
Eicosapentaenoic Acid administration & dosage
Norway epidemiology
Male
Cohort Studies
Prenatal Exposure Delayed Effects epidemiology
Risk Factors
Child
Diabetes Mellitus, Type 1 epidemiology
Fatty Acids, Omega-3 administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0428
- Volume :
- 67
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 38502240
- Full Text :
- https://doi.org/10.1007/s00125-024-06125-4