Bypassing Ammonia: From N 2 to Nitrogen Heterocycles without N 1 Intermediates or Transition Metals.

Authors :: Weber M
Kupfer T
Arrowsmith M
Dewhurst RD
Rang M
Ritschel B
Titlbach S
Ernst M
Rodrigues MO
da Silva Júnior EN
Braunschweig H
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 May 21; Vol. 63 (21), pp. e202402777. Date of Electronic Publication: 2024 Apr 11.
Publication Year :: 2024
Abstract: Diboradiazene compounds, derived in one step from the boron-mediated reduction of dinitrogen (N <subscript>2</subscript> ), were treated separately with sulfur and acetic anhydride, providing heterocyclic compounds that are BN isosteres of thiophene and 1,3-oxazole, respectively. These simple reactions represent the final steps in two-step routes to complex heterocycles from N <subscript>2</subscript> that both circumvent the need for transition metal reagents and completely bypass the traditional intermediate ammonia.<br /> (© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

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