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Selectivity in Rh-catalysis with gem -difluorinated cyclopropanes.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Apr 02; Vol. 60 (28), pp. 3764-3773. Date of Electronic Publication: 2024 Apr 02. - Publication Year :
- 2024
-
Abstract
- Small-ring chemistry is a fascinating field in organic chemistry. gem -Difluorinated cyclopropanes, a unique class of cyclopropanes, have garnered significant interest due to their intrinsic high reactivity. In this context, gem -difluorinated cyclopropanes have been extensively investigated as fluoroallylic synthons in Pd-catalyzed ring-opening/cross-coupling reactions for the synthesis of monofluoroalkenes with linear or branched selectivity. In contrast, Rh-catalysis has revealed diverse selectivity in the reaction of gem -difluorinated cyclopropanes, such as regioselectivity, enantioselectivity, and chemoselectivity. This feature article aims to summarize our efforts towards developing Rh-catalyzed reactions of gem -difluorinated cyclopropanes, briefly discussing the design, selectivity, reaction mechanisms and future research prospects.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 60
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38501197
- Full Text :
- https://doi.org/10.1039/d4cc00793j