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Malignant progression of preleukemic disorders.
- Source :
-
Blood [Blood] 2024 May 30; Vol. 143 (22), pp. 2245-2255. - Publication Year :
- 2024
-
Abstract
- Abstract: The spectrum of myeloid disorders ranges from aplastic bone marrow failure characterized by an empty bone marrow completely lacking in hematopoiesis to acute myeloid leukemia in which the marrow space is replaced by undifferentiated leukemic blasts. Recent advances in the capacity to sequence bulk tumor population as well as at a single-cell level has provided significant insight into the stepwise process of transformation to acute myeloid leukemia. Using models of progression in the context of germ line predisposition (trisomy 21, GATA2 deficiency, and SAMD9/9L syndrome), premalignant states (clonal hematopoiesis and clonal cytopenia of unknown significance), and myelodysplastic syndrome, we review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to acute myeloid leukemia. Despite major advances in our understanding, preventing the progression of these disorders or treating them at the acute leukemia phase remains a major area of unmet medical need.<br /> (© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.)
- Subjects :
- Humans
Preleukemia pathology
Preleukemia genetics
Myelodysplastic Syndromes pathology
Myelodysplastic Syndromes genetics
Leukemia, Myeloid, Acute pathology
Leukemia, Myeloid, Acute genetics
Animals
Precancerous Conditions pathology
Precancerous Conditions genetics
Mutation
Cell Transformation, Neoplastic genetics
Cell Transformation, Neoplastic pathology
Cell Transformation, Neoplastic metabolism
Disease Progression
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 143
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 38498034
- Full Text :
- https://doi.org/10.1182/blood.2023020817