A Case of Pan-TRK Positive Dermatofibrosarcoma Protuberans Located on the Nose.

Authors :: Teshima R
Hitaka T
Sugino H
Okada E
Sawada Y
Source :: Cureus [Cureus] 2024 Feb 14; Vol. 16 (2), pp. e54215. Date of Electronic Publication: 2024 Feb 14 (Print Publication: 2024).
Publication Year :: 2024
Abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare and infiltrative soft tissue tumor. Our report details a distinctive case of DFSP with pan-TRK positivity in the right nasal dorsum of a 46-year-old female. Histological analysis identified NTRK fusion gene involvement in this patient, detectable through pan-TRK immunostaining. The case underscores the significance of comprehensive management for pan-TRK-positive DFSP in challenging facial locations, indicating the potential efficacy of TRK inhibitors.<br />Competing Interests: The authors have declared that no competing interests exist.<br /> (Copyright © 2024, Teshima et al.)