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Critical role of exosome, exosomal non-coding RNAs and non-coding RNAs in head and neck cancer angiogenesis.

Authors :
Jasim SA
Al-Hawary SIS
Kaur I
Ahmad I
Hjazi A
Petkov I
Ali SHJ
Redhee AH
Shuhata Alubiady MH
Al-Ani AM
Source :
Pathology, research and practice [Pathol Res Pract] 2024 Apr; Vol. 256, pp. 155238. Date of Electronic Publication: 2024 Mar 07.
Publication Year :
2024

Abstract

Head and neck cancer (HNC) refers to the epithelial malignancies of the upper aerodigestive tract. HNCs have a constant yet slow-growing rate with an unsatisfactory overall survival rate globally. The development of new blood vessels from existing blood conduits is regarded as angiogenesis, which is implicated in the growth, progression, and metastasis of cancer. Aberrant angiogenesis is a known contributor to human cancer progression. Representing a promising therapeutic target, the blockade of angiogenesis aids in the reduction of the tumor cells oxygen and nutrient supplies. Despite the promise, the association of existing anti-angiogenic approaches with severe side effects, elevated cancer regrowth rates, and limited survival advantages is incontrovertible. Exosomes appear to have an essential contribution to the support of vascular proliferation, the regulation of tumor growth, tumor invasion, and metastasis, as they are a key mediator of information transfer between cells. In the exocrine region, various types of noncoding RNAs (ncRNAs) identified to be enriched and stable and contribute to the occurrence and progression of cancer. Mounting evidence suggest that exosome-derived ncRNAs are implicated in tumor angiogenesis. In this review, the characteristics of angiogenesis, particularly in HNC, and the impact of ncRNAs on HNC angiogenesis will be outlined. Besides, we aim to provide an insight on the regulatory role of exosomes and exosome-derived ncRNAs in angiogenesis in different types of HNC.<br />Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors are thankful to the Deanship of Scientific Research, King Khalid University, Abha, Saudi Arabia, for financially supporting this work through the Large Research Group Project under Grant no. R.G.P.2/557/44.<br /> (Copyright © 2024. Published by Elsevier GmbH.)

Details

Language :
English
ISSN :
1618-0631
Volume :
256
Database :
MEDLINE
Journal :
Pathology, research and practice
Publication Type :
Academic Journal
Accession number :
38493725
Full Text :
https://doi.org/10.1016/j.prp.2024.155238