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Characteristics of chronic lymphocytic leukemia in Japan: Comprehensive analysis of the CLLRSG-01 study.
- Source :
-
International journal of hematology [Int J Hematol] 2024 Jun; Vol. 119 (6), pp. 686-696. Date of Electronic Publication: 2024 Mar 16. - Publication Year :
- 2024
-
Abstract
- Chronic lymphocytic leukemia (CLL) is rare in Japan. We conducted the nationwide, prospective observational study CLLRSG-01 to clarify the current state of CLL in Japan and to make accurate international comparisons by preparing naturally air-dried smears like those used in other countries. Of the 201 untreated patients enrolled and evaluated, 119 were diagnosed with CLL and 82 with non-CLL mature B-cell neoplasms, based on the WHO classification. Of the 119 CLL patients, 90 were classified as typical and 29 as atypical according to FAB classification morphology, with the proportion of atypical CLL consistent with reports from other countries. Immunophenotypic analyses by flow cytometry showed that 55% of Japanese CLL patients had a Matutes score of 4 or higher, which is lower than the rate of about 90% in Europeans. Mutated IGHV was identified in 80% of Japanese CLL patients, which is a higher rate than in Western patients. The most frequent IGHV gene was VH3-30 (15%), followed by VH3-23 (12%) and VH4-34 (10%). VH1-69, the most common gene in Western countries, was identified in only one patient. These results indicate that the pattern of immunophenotypes and IGHV gene usage in Japanese CLL patients differs from that in Western patients.<br /> (© 2024. Japanese Society of Hematology.)
- Subjects :
- Humans
Japan epidemiology
Aged
Male
Female
Middle Aged
Aged, 80 and over
Prospective Studies
Adult
Mutation
Immunoglobulin Heavy Chains genetics
Immunoglobulin Variable Region genetics
Leukemia, Lymphocytic, Chronic, B-Cell genetics
Leukemia, Lymphocytic, Chronic, B-Cell epidemiology
Leukemia, Lymphocytic, Chronic, B-Cell diagnosis
Immunophenotyping
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 119
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 38492198
- Full Text :
- https://doi.org/10.1007/s12185-024-03741-z