Back to Search Start Over

Dual role of mesenchymal stem/stromal cells and their cell-free extracellular vesicles in colorectal cancer.

Authors :
Saadh MJ
Mohamed AH
Almoyad MAA
Allela OQB
Amin AH
Malquisto AA
Jin WT
Sârbu I
AlShamsi F
Elsaid FG
Akhavan-Sigari R
Source :
Cell biochemistry and function [Cell Biochem Funct] 2024 Mar; Vol. 42 (2), pp. e3962.
Publication Year :
2024

Abstract

Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell-cell interactions as well as the secretion of paracrine factors in the tissue microenvironment. For several years, exosomes have been used as a cell-free therapy to regulate the fate of tumor cells in a tumor microenvironment. This review discusses the recent advances and current understanding of assessing MSC-derived exosomes for possible cell-free therapy in CRC.<br /> (© 2024 John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1099-0844
Volume :
42
Issue :
2
Database :
MEDLINE
Journal :
Cell biochemistry and function
Publication Type :
Academic Journal
Accession number :
38491792
Full Text :
https://doi.org/10.1002/cbf.3962