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Synthetic Approaches to the New Drugs Approved During 2022.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4376-4418. Date of Electronic Publication: 2024 Mar 15. - Publication Year :
- 2024
-
Abstract
- In 2022, 23 new small molecule chemical entities were approved as drugs by the United States FDA, European Union EMA, Japan PMDA, and China NMPA. This review describes the synthetic approach demonstrated on largest scale for each new drug based on patent or primary literature. The synthetic routes highlight practical methods to construct molecules, sometimes on the manufacturing scale, to access the new drugs. Ten additional drugs approved in 2021 and one approved in 2020 are included that were not covered in the previous year's review.
- Subjects :
- United States
Japan
United States Food and Drug Administration
China
Drug Approval
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4804
- Volume :
- 67
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38488755
- Full Text :
- https://doi.org/10.1021/acs.jmedchem.3c02374