Monogenic Kidney Diseases in Kidney Transplantation.

Authors :: Gillion V
Devresse A
Olinger E
Dahlqvist G
Demoulin N
Godefroid N
Claes K
Devuyst O
Kanaan N
Source :: Kidney international reports [Kidney Int Rep] 2023 Dec 13; Vol. 9 (3), pp. 549-568. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2024).
Publication Year :: 2023
Abstract: Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases (ESKDs) in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure (KF), kidney transplantation (KT) is the preferred mode of replacement therapy. KT requires specific considerations depending on the nature of the genetic disorder, the potential oncological risk, the risk of recurrence in the graft, the possibility of specific complications of immunosuppression, and the issue of living donation. The availability of genetic testing should play an increasing role in the evaluation of patients or related living donor candidates before transplantation, relevant for the pretransplantation and posttransplantation management.<br /> (© 2023 International Society of Nephrology. Published by Elsevier Inc.)