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Interaction Between Microbubbles and Microwave Ablation: A Phantom and Rabbit Model.
- Source :
-
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [J Ultrasound Med] 2024 Jun; Vol. 43 (6), pp. 1143-1151. Date of Electronic Publication: 2024 Mar 12. - Publication Year :
- 2024
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Abstract
- Objectives: This study aimed to explore the interactions between microbubbles and microwave ablation (MWA).<br />Methods: The study employed custom-made phantoms (in vitro) and white New Zealand rabbits (in vivo). MWA was performed with or without microbubbles in the phantoms (2â×â10 <superscript>5</superscript> particles mL <superscript>-1</superscript> ) and rabbit livers (intravenous injection of 0.05âmL/kg SonoVue). During the MWA, K-type thermocouple probes were used to monitor the MWA-induced temperature increase. Contrast-enhanced ultrasound imaging (CEUS) was used to monitor and analyze the microbubbles signal intensity. After MWA, the ablation-zone volumes were evaluated and compared between the groups with and without microbubbles.<br />Results: In both the phantom models and rabbits, microbubbles showed no significant influence on MWA, including the ablation range and MWA-induced temperature increase. In phantoms and rabbit livers filled with microbubbles, MWA caused the formation of a gradually expanding microbubble-defect region over the ablation time. An increase in the temperature caused microbubble destruction.<br />Conclusions: Microbubbles had no significant influence on MWA. However, MWA induced the destruction of microbubbles in a temperature-dependent manner. Thus, the poor thermotolerance of microbubbles is a non-negligible barrier when using CEUS to monitor the ablation range during MWA in real-time.<br /> (© 2024 American Institute of Ultrasound in Medicine.)
Details
- Language :
- English
- ISSN :
- 1550-9613
- Volume :
- 43
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38469913
- Full Text :
- https://doi.org/10.1002/jum.16443