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Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2024 Jul; Vol. 241 (7), pp. 1417-1426. Date of Electronic Publication: 2024 Mar 12. - Publication Year :
- 2024
-
Abstract
- Ibogaine is a potent atypical psychedelic that has gained considerable attention due to its antiaddictive and antidepressant properties in preclinical and clinical studies. Previous research from our group showed that ibogaine suppresses sleep and produces an altered wakefulness state, which resembles natural REM sleep. However, after systemic administration, ibogaine is rapidly metabolized to noribogaine, which also shows antiaddictive effects but with a distinct pharmacological profile, making this drug a promising therapeutic candidate. Therefore, we still ignore whether the sleep/wake alterations depend on ibogaine or its principal metabolite noribogaine. To answer this question, we conducted polysomnographic recordings in rats following the administration of pure noribogaine. Our results show that noribogaine promotes wakefulness while reducing slow-wave sleep and blocking REM sleep, similar to our previous results reported for ibogaine administration. Thus, we shed new evidence on the mechanisms by which iboga alkaloids work in the brain.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Animals
Male
Rats
Rats, Sprague-Dawley
Sleep, Slow-Wave drug effects
Sleep, Slow-Wave physiology
Hallucinogens pharmacology
Hallucinogens administration & dosage
Electroencephalography drug effects
Sleep, REM drug effects
Wakefulness drug effects
Wakefulness physiology
Ibogaine analogs & derivatives
Ibogaine pharmacology
Ibogaine administration & dosage
Polysomnography
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2072
- Volume :
- 241
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 38467891
- Full Text :
- https://doi.org/10.1007/s00213-024-06572-2