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Automated radiosynthesis of [ 18 F]DPA-714 on a commercially available IBA Synthera®.
- Source :
-
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2024 May; Vol. 207, pp. 111257. Date of Electronic Publication: 2024 Mar 05. - Publication Year :
- 2024
-
Abstract
- The goal of this work was to develop a reliable method to produce the well-validated microglial activation PET tracer, [ <superscript>18</superscript> F]DPA-714, routinely for clinical and preclinical research using an IBA Synthera®. Optimization of literature methods included reduced precursor mass and use of TBA HCO <subscript>3</subscript> as the phase transfer agent in place of Kryptofix® 222 in a 65-min synthesis with an average activity yield of 24.6 ± 3.8% (n = 5). Successful quality control testing and process validation results are reported.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-9800
- Volume :
- 207
- Database :
- MEDLINE
- Journal :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38461627
- Full Text :
- https://doi.org/10.1016/j.apradiso.2024.111257