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Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review.

Authors :
Almajidi YQ
Ponnusankar S
Chaitanya MVNL
Marisetti AL
Hsu CY
Dhiaa AM
Saadh MJ
Pal Y
Thabit R
Adhab AH
Alsaikhan F
Narmani A
Farhood B
Source :
International journal of biological macromolecules [Int J Biol Macromol] 2024 Apr; Vol. 264 (Pt 2), pp. 130683. Date of Electronic Publication: 2024 Mar 06.
Publication Year :
2024

Abstract

Nowadays, there is a wide range of deficiencies in treatment of diseases. These limitations are correlated with the inefficient ability of current modalities in the prognosis, diagnosis, and treatment of diseases. Therefore, there is a fundamental need for the development of novel approaches to overcome the mentioned restrictions. Chitosan (CS) nanoparticles, with remarkable physicochemical and mechanical properties, are FDA-approved biomaterials with potential biomedical aspects, like serum stability, biocompatibility, biodegradability, mucoadhesivity, non-immunogenicity, anti-inflammatory, desirable pharmacokinetics and pharmacodynamics, etc. CS-based materials are mentioned as ideal bioactive materials for fabricating nanofibrous scaffolds. Sustained and controlled drug release and in situ gelation are other potential advantages of these scaffolds. This review highlights the latest advances in the fabrication of innovative CS-based nanofibrous scaffolds as potential bioactive materials in regenerative medicine and drug delivery systems, with an outlook on their future applications.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0003
Volume :
264
Issue :
Pt 2
Database :
MEDLINE
Journal :
International journal of biological macromolecules
Publication Type :
Academic Journal
Accession number :
38458289
Full Text :
https://doi.org/10.1016/j.ijbiomac.2024.130683