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Dietary composition of adult eosinophilic esophagitis patients is related to disease severity.
- Source :
-
Immunity, inflammation and disease [Immun Inflamm Dis] 2024 Mar; Vol. 12 (3), pp. e1206. - Publication Year :
- 2024
-
Abstract
- Background: In addition to the elimination diet, dietary composition may influence disease severity in patients with eosinophilic esophagitis (EoE) through modulation of the immune response.<br />Aim: To explore the immunomodulatory role of nutrition before and during elimination diet in adult EoE patients.<br />Methods: Nutritional intake was assessed in 39 Dutch adult EoE patients participating in the Supplemental Elemental Trial (Dutch trial registry NL6014, NTR6778) using 3-day food diaries. In this randomized controlled trial, diagnosed patients received either a four-food elimination diet alone (FFED) or FFED with addition of an amino acid-based formula for 6 weeks. Multiple linear regression analyses were performed to assess associations between the intake of nutrients and food groups per 1000 kCal and peak eosinophil count/high power field (PEC), both at baseline and after 6 weeks.<br />Results: At baseline, we found a statistically significant negative (thus favorable) relationship between the intake of protein, total fat, phosphorus, zinc, vitamin B12, folate, and milk products and PEC (p < .05), while calcium (p = .058) and full-fat cheese/curd (p = .056) were borderline (favorably) significant. In contrast, total carbohydrates, prepacked fruit juice, and white bread were significantly positively (unfavorable) related to PEC (p < .05), while ultra-processed meals (p = .059) were borderline (unfavorably) significant. After dietary intervention, coffee/tea were significantly negatively (favorably) related to PEC, hummus/legumes were significantly positively (unfavorably) related with PEC, while peanuts were borderline significantly positively related (p = .058).<br />Conclusion: Dietary composition may be related to inflammation in adult EoE patients. High-quality and anti-inflammatory diets may be a promising adjuvant therapy in the dietary management of EoE.<br /> (© 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Humans
Allergens
Diet
Food
Inflammation
Patient Acuity
Eosinophilic Esophagitis
Subjects
Details
- Language :
- English
- ISSN :
- 2050-4527
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunity, inflammation and disease
- Publication Type :
- Academic Journal
- Accession number :
- 38456617
- Full Text :
- https://doi.org/10.1002/iid3.1206