Back to Search
Start Over
Postradiation platinum-etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity.
- Source :
-
CNS oncology [CNS Oncol] 2024 Jun 06; Vol. 13 (1), pp. CNS107. Date of Electronic Publication: 2024 Mar 08. - Publication Year :
- 2024
-
Abstract
- Aim: Adult medulloblastomas (MB) are rare, and optimal post-craniospinal irradiation (CSI) chemotherapy is not yet defined. We investigated hematological toxicity in patients treated with platinum-etoposide (EP) post-CSI. Methods: Retrospective, single-institution study to determine hematological toxicity in adult MB patients treated with EP (1995-2022). Results: Thirteen patients with a median follow-up of 50 months (range, 10-233) were analyzed. Four discontinued treatment due to toxicity, one after 1, 3 after 3 cycles. Hematological toxicities included grade 3 (5 patients) and grade 4 (6 patients). Two patients experienced post-treatment progression and died 16 and 37 months from diagnosis. Conclusion: Post-CSI EP demonstrates acceptable hematological toxicity in adult MB. However, the small cohort precludes definitive survival outcome conclusions. Prospective studies for comprehensive comparisons with other regimens are needed in this context.
- Subjects :
- Humans
Male
Retrospective Studies
Adult
Female
Young Adult
Middle Aged
Hematologic Diseases chemically induced
Hematologic Diseases etiology
Antineoplastic Combined Chemotherapy Protocols adverse effects
Follow-Up Studies
Adolescent
Craniospinal Irradiation adverse effects
Platinum therapeutic use
Medulloblastoma radiotherapy
Medulloblastoma drug therapy
Etoposide adverse effects
Etoposide administration & dosage
Cerebellar Neoplasms radiotherapy
Cerebellar Neoplasms drug therapy
Cerebellar Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2045-0915
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- CNS oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38456492
- Full Text :
- https://doi.org/10.2217/cns-2023-0029