Back to Search
Start Over
Acute ingestion of Ibuprofen does not influence the release of IL-6 or improve self-paced exercise in the heat despite altering cortical activity.
- Source :
-
European journal of applied physiology [Eur J Appl Physiol] 2024 Aug; Vol. 124 (8), pp. 2303-2313. Date of Electronic Publication: 2024 Mar 06. - Publication Year :
- 2024
-
Abstract
- The present study tested the hypothesis that ingesting 800 mg Ibuprofen prior to self-paced cycling at a fixed rating of perceived exertion (RPE) improves performance by attenuating the release of Interleukin (IL)-6 and its signalling molecules, whilst simultaneously modulating cortical activity and cerebral oxygenation to the brain. Eight healthy, recreationally active males ingested 800 mg Ibuprofen or a placebo ~ 1 h prior to performing fixed RPE cycling for 60 min in 35 °C and 60% relative humidity at an intensity of hard to very hard (RPE = 16) with intermittent maximal (RPE = 20) sprints every 10 min. Power output (PO), core and mean skin temperatures (T <subscript>c</subscript> , T <subscript>sk</subscript> ), respectively, and heart rate (HR) were measured continuously. Electroencephalography (EEG) recordings at the frontal (Fz), motor (Cz) and Parietal (Pz) areas (90 s) were collected every 5 min. IL-6, soluble glycoprotein receptor (sgp130) and IL-6 receptor (R) were collected at pre-, 30 min and immediately post-exercise. Mean PO, HR, T <subscript>c</subscript> and T <subscript>sk</subscript> , and RPE were not different between trials (P ≥ 0.33). At end-exercise, the change in IL-6, sgp130 and sIL-6R was not different between trials (P ≥ 0.12). The increase in α and β activity did not differ in any cortices between trials (P ≥ 0.07); however, there was a significant reduction in α/β activity in the Ibuprofen compared to placebo trials at all sites (P ≤ 0.05). Ingesting a maximal, over-the-counter dose of Ibuprofen prior to exercise in the heat does not attenuate the release of IL-6, nor improve performance, but may influence cortical activity evidenced by a greater reduction in α/β activity.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Adult
Hot Temperature
Physical Exertion physiology
Physical Exertion drug effects
Heart Rate drug effects
Exercise physiology
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Cerebral Cortex physiology
Young Adult
Receptors, Interleukin-6 metabolism
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Ibuprofen pharmacology
Ibuprofen administration & dosage
Interleukin-6 metabolism
Interleukin-6 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1439-6327
- Volume :
- 124
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of applied physiology
- Publication Type :
- Academic Journal
- Accession number :
- 38446191
- Full Text :
- https://doi.org/10.1007/s00421-024-05452-z