Back to Search
Start Over
Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-Lymphocyte Ratio and Long-Term Prognosis of Living Donor Liver Transplant Recipients With Hepatocellular Carcinoma.
- Source :
-
Transplantation proceedings [Transplant Proc] 2024 Apr; Vol. 56 (3), pp. 634-639. Date of Electronic Publication: 2024 Mar 04. - Publication Year :
- 2024
-
Abstract
- Objective: Preoperative neutrophil-to-lymphocyte ratio (NLR) is a well-known prognostic indicator in various malignancies; however, the impact of postoperative NLR on living donor liver transplant (LDLT) recipients is unknown. Immunotherapy with donor liver-derived activated natural killer (NK) cells may improve postoperative NLR by coactivating immune cells or suppressing activated neutrophils. This study aims to clarify the clinical significance of postoperative NLR in recipients after LDLT with HCC and assess whether immunotherapy improves postoperative NLR.<br />Methods: We conducted a retrospective study of LDLT recipients between 2001 and 2022 to evaluate the clinical significance of postoperative NLR. Furthermore, the correlation between postoperative NLR and the activation marker of infused NK cells was also evaluated. The postoperative NLR was examined 4 weeks after LDLT.<br />Results: The postoperative high NLR group (N = 78) had preoperative lower NLR and higher model for end-stage liver disease and a higher rate of postoperative infection within 30 days after LDLT than the postoperative low NLR group (N = 41). Postoperative high NLR (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.01-6.79; P = .047) and nontreatment of immunotherapy (HR, 3.10; 95% CI, 1.33-7.22; P < .01) were independent risk factors for poor overall survival in multivariate analysis. Furthermore, the activation marker of infused NK cells is inversely correlated with decreased postoperative NLR.<br />Conclusions: The higher level of postoperative NLR was independently associated with poor prognosis in patients after LDLT with HCC. Immunotherapy using activated NK cells may improve postoperative NLR and long-term prognosis.<br />Competing Interests: Declaration of competing interest All the authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Prognosis
Lymphocytes immunology
Adult
Carcinoma, Hepatocellular surgery
Carcinoma, Hepatocellular immunology
Carcinoma, Hepatocellular therapy
Liver Transplantation
Liver Neoplasms surgery
Liver Neoplasms immunology
Neutrophils immunology
Living Donors
Killer Cells, Natural immunology
Immunotherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 56
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 38443302
- Full Text :
- https://doi.org/10.1016/j.transproceed.2024.02.002